Parvovirus associated with Endocapillary proliferative glomerulonephritis

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Journal of Kidney Treatment and Diagnosis is a peer-reviewed, Open Access journal focused on Clinical Nephrologypractice and related diseases.It covers several clinical areas of renal medicine, such as dialysis, transplantation, diabetes, anaemia, pharmacy nutrition and clinical aspects of kidney care.

Endocapillary proliferative glomerulonephritis is a form of glomerulonephritis that can be associated with nephritis. It may be associated with Parvovirus B19. Ito S, Kuriyama H, Iino N, et al. (December 2003). "Patient with diffuse mesangial and endocapillary proliferative glomerulonephritis with hypocomplementemia and elevated anti-streptolysin O treated with prednisolone, angiotensin-converting enzyme inhibitor, and angiotensin II receptor antagonist". Kano K, Nishikura K, Kojima M "A patient with membranoproliferative glomerulonephritis diagnosed by the third biopsy via endocapillary proliferative glomerulonephritis and focal membranoproliferative glomerulonephritis

Most cases are associated with the dysregulation of the alternative complement pathway. DDD is associated with deposition of complement C3 within the glomeruli with little or no staining for immunoglobulin. The presence of C3 without significant immunoglobulin suggested to early investigators that DDD was due to abnormal activation of the complement alternative pathway (AP). There is now strong evidence that DDD is caused by uncontrolled AP. These deposits elicit an immune response, causing damage to cells and structures within their vicinity. Has similar pathological findings of Type I disease. A candidate gene has been identified on chromosome 1. Complement component 3 is seen under immunofluorescence. it is associated with complement receptor 6 deficiency.

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With Regards,
John Robert                              
Managing Editor
Journal of Kidney Treatment and Diagnosis