Journal of Clinical Pharmacology and Toxicology is using Editorial Tracking System to maintain quality and transparency to the author in the peer-review process. Review processing will be performed by the editorial board members of the Journal of Clinical Pharmacology and Toxicology or by Reviewers (outside experts in the field). Two independent reviewer’s approval (Minimum reviewer’s approval) followed by editor approval is obligatory for acceptance of any manuscript excluding an editorial.

Tetracycline, sold under the brand name Sumycin. It is an antibiotic used to treat a number of infections like acne, cholera, brucellosis, plague, malaria, syphilis, gonorrhea and chlamydia. It is taken by mouth. Tetracycline is also used to treat infections you can get from direct contact with infected animals or contaminated food. In some cases, tetracycline is used when penicillin or another antibiotic cannot be used to treat serious infections such as Anthrax, Listeria, Clostridium, Actinomyces, and others. Tetracycline can also be used in combination with anti-ulcer medications to treat certain types of stomach ulcers.

Tetracycline comes as a capsule to take by mouth. It is usually taken two or four times daily. Tetracycline should be taken on an empty stomach, at least 1 hour before or 2 hours after meals or snacks. Drink a full glass of water with each dose of tetracycline. Do not take tetracycline with food, especially dairy products such as milk, yogurt, cheese, and ice cream. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take tetracycline exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Tetracycline is a short-acting antibiotic that inhibits bacterial growth by inhibiting translation. It binds to the 30S ribosomal subunit and prevents the amino-acyl tRNA from binding to the A site of the ribosome. It also binds to some extent to the 50S ribosomal subunit. This binding is reversible in nature. Additionally tetracycline may alter the cytoplasmic membrane of bacteria causing leakage of intracellular contents, such as nucleotides, from the cell. Tetracycline passively diffuses through porin channels in the bacterial membrane and reversibly binds to the 30S ribosomal subunit, preventing binding of tRNA to the mRNA-ribosome complex, and thus interfering with protein synthesis.

Antibiotics such as tetracycline will not work for colds, flu, or other viral infections. Taking this medicine during pregnancy may affect tooth and bone development in the unborn baby. Taking tetracycline during the last half of pregnancy can cause permanent tooth discoloration later in the baby's life. Tell your doctor if you are pregnant or if you become pregnant while using this medicine. Tetracycline can make birth control pills less effective. Tetracycline can pass into breast milk and may affect bone and tooth development in a nursing infant. Do not breast-feed while you are taking tetracycline.

The allergic reactions of tetracycline include hives; difficult breathing; swelling of your face, lips, tongue, or throat. Other adverse effects include severe blistering, peeling, red skin rash, fever, chills, body aches, flu symptoms, pale or yellowed skin, easy bruising or bleeding and any signs of a new infection. Common tetracycline side effects may include: nausea, vomiting, diarrhea, upset stomach, loss of appetite, white patches or sores inside your mouth or on your lips, swollen tongue, black or "hairy" tongue, trouble swallowing, sores or swelling in your rectal or genital area and vaginal itching or discharge. Some products that may interact with this drug include: atovaquone, retinoid medications taken by mouth, strontium, digoxin, kaolin pectin and warfarin.

On the occasion of its 3 years, Successful Journey, Journal of Clinical Pharmacology and Toxicology decided to provide a partial waiver on its article processing charges to promote quality research from across the nations of the globe to encourage the latest research in the field of Infections, Diseases and Medicine. Journal of Clinical Pharmacology and Toxicology also planning to release a special issue on its new approaches.

Regards

Mary Wilson

Editorial office

Journal of Clinical Pharmacology and Toxicology

E-mail: pharmatoxicol@eclinicalsci.com